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A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation
Inhibition of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome has recently emerged as a promising therapeutic target for several inflammatory diseases. After priming and activation by inflammation triggers, NLRP3 forms a complex with apoptosis-associated speck-like protein c...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8319173/ https://ncbi.nlm.nih.gov/pubmed/34321581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-94850-w |
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