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Nanoscale, automated, high throughput synthesis and screening for the accelerated discovery of protein modifiers

Hit finding in early drug discovery is often based on high throughput screening (HTS) of existing and historical compound libraries, which can limit chemical diversity, is time-consuming, very costly, and environmentally not sustainable. On-the-fly compound synthesis and in situ screening in a highl...

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Detalhes bibliográficos
Publicado no:RSC Med Chem
Main Authors: Gao, Kai, Shaabani, Shabnam, Xu, Ruixue, Zarganes-Tzitzikas, Tryfon, Gao, Li, Ahmadianmoghaddam, Maryam, Groves, Matthew R., Dömling, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: RSC 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8152715/
https://ncbi.nlm.nih.gov/pubmed/34124680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1md00087j
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