High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter

The thiazide-sensitive sodium-chloride cotransporter (NCC) in the renal distal convoluted tubule (DCT) plays a critical role in regulating blood pressure (BP) and K(+) homeostasis. During hyperkalemia, reduced NCC phosphorylation and total NCC abundance facilitate downstream electrogenic K(+) secret...

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Gepubliceerd in:J Biol Chem
Hoofdauteurs: Kortenoeven, Marleen L.A., Esteva-Font, Cristina, Dimke, Henrik, Poulsen, Søren B., Murali, Sathish K., Fenton, Robert A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318901/
https://ncbi.nlm.nih.gov/pubmed/34174287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100915
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