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High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter
The thiazide-sensitive sodium-chloride cotransporter (NCC) in the renal distal convoluted tubule (DCT) plays a critical role in regulating blood pressure (BP) and K(+) homeostasis. During hyperkalemia, reduced NCC phosphorylation and total NCC abundance facilitate downstream electrogenic K(+) secret...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8318901/ https://ncbi.nlm.nih.gov/pubmed/34174287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100915 |
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