A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance

Activation of the STAT5 transcription factor downstream of the Interleukin-2 receptor (IL-2R) induces expression of Foxp3, a critical step in the differentiation of regulatory T (Treg) cells. Due to the pleiotropic effects of IL-2R signaling, it is unclear how STAT5 acts directly on the Foxp3 locus...

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Bibliografske podrobnosti
izdano v:Immunity
Main Authors: Dikiy, Stanislav, Li, Jun, Bai, Lu, Jiang, Menglin, Janke, Laura, Zong, Xinying, Hao, Xiaolei, Hoyos, Beatrice, Wang, Zhong-Min, Xu, Beisi, Fan, Yiping, Rudensky, Alexander Y., Feng, Yongqiang
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317508/
https://ncbi.nlm.nih.gov/pubmed/33838102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.03.020
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