Foxp3 enhancers synergize to maximize regulatory T cell suppressive capacity

T reg cells bearing a diverse antigen receptor repertoire suppress pathogenic T cells and maintain immune homeostasis during their long lifespan. How their robust function is determined genetically remains elusive. Here, we investigate the regulatory space of the cis-regulatory elements of T reg lin...

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Udgivet i:J Exp Med
Main Authors: Zong, Xinying, Hao, Xiaolei, Xu, Beisi, Crawford, Jeremy Chase, Wright, Shaela, Li, Jun, Zhang, Yang, Bai, Lu, He, Minghong, Jiang, Menglin, Fan, Yiping, Connelly, Jon P., Pruett-Miller, Shondra M., Berns, Hartmut, Janke, Laura, Li, Chunliang, Feng, Yongqiang
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185987/
https://ncbi.nlm.nih.gov/pubmed/34086055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202415
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