Design, Synthesis, and Pharmacological Evaluation of Analogs Derived from the PLEV Tetrapeptide as Protein-Protein Interaction Modulators of Voltage-Gated Sodium Channel 1.6

The voltage-gated Na(+) (Na(v)) channel is the molecular determinant of excitability. Disruption of protein-protein interactions (PPIs) between Na(v)1.6 and fibroblast growth factor 14 (FGF14) leads to impaired excitability of neurons in clinically relevant brain areas associated with channelopathie...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Wang, Pingyuan, Wadsworth, Paul A., Dvorak, Nolan M., Singh, Aditya K., Chen, Haiying, Liu, Zhiqing, Zhou, Richard, Holthauzen, Luis Marcelo F., Zhou, Jia, Laezza, Fernanda
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317200/
https://ncbi.nlm.nih.gov/pubmed/33054193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00531
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak