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Development of Allosteric Modulators of Voltage-Gated Na(+) Channels: A Novel Approach for an Old Target

Given their primacy in governing the action potential (AP) of excitable cells, voltage-gated Na+ (Na(v)) channels are important pharmacological targets of therapeutics for a diverse array of clinical indications. Despite historically being a traditional drug target, therapeutics targeting Na(v) chan...

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Detalhes bibliográficos
Publicado no:Curr Top Med Chem
Main Authors: Dvorak, Nolan M., Wadsworth, Paul A., Wang, Pingyuan, Zhou, Jia, Laezza, Fernanda
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8272397/
https://ncbi.nlm.nih.gov/pubmed/34036922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1568026621666210525105359
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