Otoferlin Is Required for Proper Synapse Maturation and for Maintenance of Inner and Outer Hair Cells in Mouse Models for DFNB9

Deficiency of otoferlin causes profound prelingual deafness in humans and animal models. Here, we closely analyzed developmental deficits and degenerative mechanisms in Otof knock-out (Otof(–/–)) mice over the course of 48 weeks. We found otoferlin to be required for proper synapse development in th...

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Xehetasun bibliografikoak
Argitaratua izan da:Front Cell Neurosci
Egile Nagusiak: Stalmann, Ursula, Franke, Albert Justin, Al-Moyed, Hanan, Strenzke, Nicola, Reisinger, Ellen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2021
Gaiak:
Neuroscience
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316924/
https://ncbi.nlm.nih.gov/pubmed/34335185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2021.677543
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