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Otoferlin Is Required for Proper Synapse Maturation and for Maintenance of Inner and Outer Hair Cells in Mouse Models for DFNB9
Deficiency of otoferlin causes profound prelingual deafness in humans and animal models. Here, we closely analyzed developmental deficits and degenerative mechanisms in Otof knock-out (Otof(–/–)) mice over the course of 48 weeks. We found otoferlin to be required for proper synapse development in th...
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| Udgivet i: | Front Cell Neurosci |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8316924/ https://ncbi.nlm.nih.gov/pubmed/34335185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2021.677543 |
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