Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

Neutralizing antibodies (nAbs) hold promise as therapeutics against COVID-19. Here, we describe protein engineering and modular design principles that have led to the development of synthetic bivalent and tetravalent nAbs against SARS-CoV-2. The best nAb targets the host receptor binding site of the...

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Dettagli Bibliografici
Pubblicato in:J Mol Biol
Autori principali: Miersch, Shane, Li, Zhijie, Saberianfar, Reza, Ustav, Mart, Brett Case, James, Blazer, Levi, Chen, Chao, Ye, Wei, Pavlenco, Alevtina, Gorelik, Maryna, Garcia Perez, Julia, Subramania, Suryasree, Singh, Serena, Ploder, Lynda, Ganaie, Safder, Chen, Rita E., Leung, Daisy W., Pandolfi, Pier Paolo, Novelli, Giuseppe, Matusali, Giulia, Colavita, Francesca, Capobianchi, Maria R., Jain, Suresh, Gupta, J.B., Amarasinghe, Gaya K., Diamond, Michael S., Rini, James, Sidhu, Sachdev S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Published by Elsevier Ltd. 2021
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316672/
https://ncbi.nlm.nih.gov/pubmed/34329642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.167177
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