Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

Neutralizing antibodies (nAbs) hold promise as therapeutics against COVID-19. Here, we describe protein engineering and modular design principles that have led to the development of synthetic bivalent and tetravalent nAbs against SARS-CoV-2. The best nAb targets the host receptor binding site of the...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Miersch, Shane, Li, Zhijie, Saberianfar, Reza, Ustav, Mart, Brett Case, James, Blazer, Levi, Chen, Chao, Ye, Wei, Pavlenco, Alevtina, Gorelik, Maryna, Garcia Perez, Julia, Subramania, Suryasree, Singh, Serena, Ploder, Lynda, Ganaie, Safder, Chen, Rita E., Leung, Daisy W., Pandolfi, Pier Paolo, Novelli, Giuseppe, Matusali, Giulia, Colavita, Francesca, Capobianchi, Maria R., Jain, Suresh, Gupta, J.B., Amarasinghe, Gaya K., Diamond, Michael S., Rini, James, Sidhu, Sachdev S.
Formato: Artigo
Idioma:Inglês
Publicado em: Published by Elsevier Ltd. 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316672/
https://ncbi.nlm.nih.gov/pubmed/34329642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.167177
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados