An enzymatic activation of formaldehyde for nucleotide methylation

Folate enzyme cofactors and their derivatives have the unique ability to provide a single carbon unit at different oxidation levels for the de novo synthesis of amino-acids, purines, or thymidylate, an essential DNA nucleotide. How these cofactors mediate methylene transfer is not fully settled yet,...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bou-Nader, Charles, Stull, Frederick W., Pecqueur, Ludovic, Simon, Philippe, Guérineau, Vincent, Royant, Antoine, Fontecave, Marc, Lombard, Murielle, Palfey, Bruce A., Hamdane, Djemel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316439/
https://ncbi.nlm.nih.gov/pubmed/34315871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24756-8
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