An extended dsRBD is required for post-transcriptional modification in human tRNAs

In tRNA, dihydrouridine is a conserved modified base generated by the post-transcriptional reduction of uridine. Formation of dihydrouridine 20, located in the D-loop, is catalyzed by dihydrouridine synthase 2 (Dus2). Human Dus2 (HsDus2) expression is upregulated in lung cancers, offering a growth a...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Bou-Nader, Charles, Pecqueur, Ludovic, Bregeon, Damien, Kamah, Amina, Guérineau, Vincent, Golinelli-Pimpaneau, Béatrice, Guimarães, Beatriz G., Fontecave, Marc, Hamdane, Djemel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
Nucleic Acid Enzymes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627097/
https://ncbi.nlm.nih.gov/pubmed/26429968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv989
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