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An extended dsRBD is required for post-transcriptional modification in human tRNAs
In tRNA, dihydrouridine is a conserved modified base generated by the post-transcriptional reduction of uridine. Formation of dihydrouridine 20, located in the D-loop, is catalyzed by dihydrouridine synthase 2 (Dus2). Human Dus2 (HsDus2) expression is upregulated in lung cancers, offering a growth a...
Enregistré dans:
| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4627097/ https://ncbi.nlm.nih.gov/pubmed/26429968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv989 |
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