Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines

Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for the antiproliferative effect of tankyrase inhibition (TNKSi). The TNKS1/2-speci...

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Détails bibliographiques
Publié dans:iScience
Auteurs principaux: Mygland, Line, Brinch, Shoshy Alam, Strand, Martin Frank, Olsen, Petter Angell, Aizenshtadt, Aleksandra, Lund, Kaja, Solberg, Nina Therese, Lycke, Max, Thorvaldsen, Tor Espen, Espada, Sandra, Misaghian, Dorna, Page, Christian M., Agafonov, Oleg, Nygård, Ståle, Chi, Nai-Wen, Lin, Eva, Tan, Jenille, Yu, Yihong, Costa, Mike, Krauss, Stefan, Waaler, Jo
Format: Artigo
Langue:Inglês
Publié: Elsevier 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313754/
https://ncbi.nlm.nih.gov/pubmed/34337362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102807
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