Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

[Image: see text] Tankyrases 1 and 2 are central biotargets in the WNT/β-catenin signaling and Hippo signaling pathways. We have previously developed tankyrase inhibitors bearing a 1,2,4-triazole moiety and binding predominantly to the adenosine binding site of the tankyrase catalytic domain. Here w...

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Pubblicato in:J Med Chem
Autori principali: Waaler, Jo, Leenders, Ruben G. G., Sowa, Sven T., Alam Brinch, Shoshy, Lycke, Max, Nieczypor, Piotr, Aertssen, Sjoerd, Murthy, Sudarshan, Galera-Prat, Albert, Damen, Eddy, Wegert, Anita, Nazaré, Marc, Lehtiö, Lari, Krauss, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008393/
https://ncbi.nlm.nih.gov/pubmed/32511917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00208
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