Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines

Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for the antiproliferative effect of tankyrase inhibition (TNKSi). The TNKS1/2-speci...

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Publicado no:iScience
Main Authors: Mygland, Line, Brinch, Shoshy Alam, Strand, Martin Frank, Olsen, Petter Angell, Aizenshtadt, Aleksandra, Lund, Kaja, Solberg, Nina Therese, Lycke, Max, Thorvaldsen, Tor Espen, Espada, Sandra, Misaghian, Dorna, Page, Christian M., Agafonov, Oleg, Nygård, Ståle, Chi, Nai-Wen, Lin, Eva, Tan, Jenille, Yu, Yihong, Costa, Mike, Krauss, Stefan, Waaler, Jo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313754/
https://ncbi.nlm.nih.gov/pubmed/34337362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102807
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