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Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity
In canonical Wnt signaling, the protein levels of the key signaling mediator β-catenin are under tight regulation by the multimeric destruction complex that mediates proteasomal degradation of β-catenin. In colorectal cancer, destruction complex activity is often compromised due to mutations in the...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4970726/ https://ncbi.nlm.nih.gov/pubmed/27482906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160507 |
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