Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles

As part of the lysosomal degradation pathway, the endosomal sorting complexes required for transport (ESCRT-0 to -III/VPS4) sequester receptors at the endosome and simultaneously deform the membrane to generate intraluminal vesicles (ILVs). Whereas ESCRT-III/VPS4 have an established function in ILV...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Liese, Susanne, Wenzel, Eva Maria, Kjos, Ingrid, Rojas Molina, Rossana, Schultz, Sebastian W., Brech, Andreas, Stenmark, Harald, Raiborg, Camilla, Carlson, Andreas
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2020
Sujets:
Physical Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682568/
https://ncbi.nlm.nih.gov/pubmed/33139578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014228117
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