ADAR and hnRNPC deficiency synergize in activating endogenous dsRNA-induced type I IFN responses

Cytosolic double-stranded RNA (dsRNA) initiates type I IFN responses. Endogenous retroelements, notably Alu elements, constitute a source of dsRNA. Adenosine-to-inosine (A-to-I) editing by ADAR induces mismatches in dsRNA and prevents recognition by MDA5 and autoinflammation. To identify additional...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Exp Med
Autori principali: Herzner, Anna-Maria, Khan, Zia, Van Nostrand, Eric L., Chan, Sara, Cuellar, Trinna, Chen, Ronald, Pechuan-Jorge, Ximo, Komuves, Laszlo, Solon, Margaret, Modrusan, Zora, Haley, Benjamin, Yeo, Gene W., Behrens, Timothy W., Albert, Matthew L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2021
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313407/
https://ncbi.nlm.nih.gov/pubmed/34297039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201833
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi