ADAR and hnRNPC deficiency synergize in activating endogenous dsRNA-induced type I IFN responses

Cytosolic double-stranded RNA (dsRNA) initiates type I IFN responses. Endogenous retroelements, notably Alu elements, constitute a source of dsRNA. Adenosine-to-inosine (A-to-I) editing by ADAR induces mismatches in dsRNA and prevents recognition by MDA5 and autoinflammation. To identify additional...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Herzner, Anna-Maria, Khan, Zia, Van Nostrand, Eric L., Chan, Sara, Cuellar, Trinna, Chen, Ronald, Pechuan-Jorge, Ximo, Komuves, Laszlo, Solon, Margaret, Modrusan, Zora, Haley, Benjamin, Yeo, Gene W., Behrens, Timothy W., Albert, Matthew L.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313407/
https://ncbi.nlm.nih.gov/pubmed/34297039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201833
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados