An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation

Serine incorporator 5 (SERINC5) reduces the infectivity of progeny HIV-1 virions by incorporating into the outer host-derived viral membrane during egress. To counter SERINC5, the HIV-1 accessory protein Nef triggers SERINC5 internalization by engaging the adaptor protein 2 (AP-2) complex using the...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Mumby, Mitchell J., Johnson, Aaron L., Trothen, Steven M., Edgar, Cassandra R., Gibson, Richard, Stathopulos, Peter B., Arts, Eric J., Dikeakos, Jimmy D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2021
Matèries:
Virus-Cell Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312866/
https://ncbi.nlm.nih.gov/pubmed/34037423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00588-21
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