α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice

Inflammation and extracellular matrix (ECM) degradation have been implicated in the pathological process of osteoarthritis (OA). α-Cyperone is the main active component of the traditional Chinese medicine Cyperus rotundus L. In this study, we found that α-Cyperone abolished the IL-1β-induced product...

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Podrobná bibliografie
Vydáno v:Aging (Albany NY)
Hlavní autoři: Zhang, Huawei, Li, Sunlong, Lu, Jiajie, Jin, Jie, Zhu, Gaosheng, Wang, Libo, Yan, Yingzhao, He, Linjie, Wang, Ben, Wang, Xiangyang, Yu, Huachen
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312409/
https://ncbi.nlm.nih.gov/pubmed/34237707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.203259
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