α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice

Inflammation and extracellular matrix (ECM) degradation have been implicated in the pathological process of osteoarthritis (OA). α-Cyperone is the main active component of the traditional Chinese medicine Cyperus rotundus L. In this study, we found that α-Cyperone abolished the IL-1β-induced product...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Zhang, Huawei, Li, Sunlong, Lu, Jiajie, Jin, Jie, Zhu, Gaosheng, Wang, Libo, Yan, Yingzhao, He, Linjie, Wang, Ben, Wang, Xiangyang, Yu, Huachen
Format: Artigo
Language:Inglês
Published: Impact Journals 2021
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312409/
https://ncbi.nlm.nih.gov/pubmed/34237707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.203259
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