Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain

[Image: see text] CREBBP (CBP/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that are essential for human development. They each comprise 10 domains through which they interact with >400 proteins, making them important transcriptional co-activators and key nodes in th...

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সংরক্ষণ করুন:
গ্রন্থ-পঞ্জীর বিবরন
প্রকাশিত:J Med Chem
প্রধান লেখক: Brand, Michael, Clayton, James, Moroglu, Mustafa, Schiedel, Matthias, Picaud, Sarah, Bluck, Joseph P., Skwarska, Anna, Bolland, Hannah, Chan, Anthony K. N., Laurin, Corentine M. C., Scorah, Amy R., See, Larissa, Rooney, Timothy P. C., Andrews, Katrina H., Fedorov, Oleg, Perell, Gabriella, Kalra, Prakriti, Vinh, Kayla B., Cortopassi, Wilian A., Heitel, Pascal, Christensen, Kirsten E., Cooper, Richard I., Paton, Robert S., Pomerantz, William C. K., Biggin, Philip C., Hammond, Ester M., Filippakopoulos, Panagis, Conway, Stuart J.
বিন্যাস: Artigo
ভাষা:Inglês
প্রকাশিত: American Chemical Society 2021
অনলাইন ব্যবহার করুন:https://ncbi.nlm.nih.gov/pmc/articles/PMC8311651/
https://ncbi.nlm.nih.gov/pubmed/34255515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c00348
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