Small Molecule–Peptide Conjugates as Dimerization Inhibitors of Leishmania infantum Trypanothione Disulfide Reductase

Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously obtained proof of concept that disrupting protein–protein interactions at the...

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Vydáno v:Pharmaceuticals (Basel)
Hlavní autoři: Revuelto, Alejandro, López-Martín, Isabel, de Lucio, Héctor, García-Soriano, Juan Carlos, Zanda, Nicola, de Castro, Sonia, Gago, Federico, Jiménez-Ruiz, Antonio, Velázquez, Sonsoles, Camarasa, María-José
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8308777/
https://ncbi.nlm.nih.gov/pubmed/34358115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14070689
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