Tetranucleotide and Low Microsatellite Instability Are Inversely Associated with the CpG Island Methylator Phenotype in Colorectal Cancer

SIMPLE SUMMARY: A type of DNA mismatch repair defect known as “elevated microsatellite alterations at selected tetranucleotide repeats” (EMAST) is found across many different cancers. Tetranucleotide microsatellite instability, which is caused by MSH3 mismatch repair gene/protein loss-of-function, s...

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Udgivet i:Cancers (Basel)
Main Authors: Meessen, Sabine, Currey, Nicola, Jahan, Zeenat, Parker, Hannah W., Jenkins, Mark A., Buchanan, Daniel D., Hopper, John L., Segelov, Eva, Dahlstrom, Jane E., Kohonen-Corish, Maija R. J.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8308094/
https://ncbi.nlm.nih.gov/pubmed/34298744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13143529
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