Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer

SIMPLE SUMMARY: Hyperactivation of the canonical Wnt and inactivation of the Hippo pathway are well-known genetic backgrounds for familial adenomatosis polyposis (FAP) and colorectal cancer (CRC), although the reciprocal regulation between those pathways is not yet clear. In this study, we found tha...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Kang, Hee Eun, Seo, Yoojeong, Yun, Jun Seop, Song, Sang Hyun, Han, Dawool, Cho, Eunae Sandra, Cho, Sue Bean, Jeon, Yoon, Lee, Ho, Kim, Hyun Sil, Kang, Joyeon, Yook, Jong In, Kim, Nam Hee, Kim, Tae Il
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8308039/
https://ncbi.nlm.nih.gov/pubmed/34298652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13143437
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