In Vitro and In Silico Characterization of an Antimalarial Compound with Antitumor Activity Targeting Human DNA Topoisomerase IB

Human DNA topoisomerase IB controls the topological state of supercoiled DNA through a complex catalytic cycle that consists of cleavage and religation reactions, allowing the progression of fundamental DNA metabolism. The catalytic steps of human DNA topoisomerase IB were analyzed in the presence o...

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Bibliografiset tiedot
Julkaisussa:Int J Mol Sci
Päätekijät: Soren, Bini Chhetri, Babu Dasari, Jagadish, Ottaviani, Alessio, Messina, Beatrice, Andreotti, Giada, Romeo, Alice, Iacovelli, Federico, Falconi, Mattia, Desideri, Alessandro, Fiorani, Paola
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8306514/
https://ncbi.nlm.nih.gov/pubmed/34299074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147455
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