In Vitro and In Silico Characterization of an Antimalarial Compound with Antitumor Activity Targeting Human DNA Topoisomerase IB

Human DNA topoisomerase IB controls the topological state of supercoiled DNA through a complex catalytic cycle that consists of cleavage and religation reactions, allowing the progression of fundamental DNA metabolism. The catalytic steps of human DNA topoisomerase IB were analyzed in the presence o...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Soren, Bini Chhetri, Babu Dasari, Jagadish, Ottaviani, Alessio, Messina, Beatrice, Andreotti, Giada, Romeo, Alice, Iacovelli, Federico, Falconi, Mattia, Desideri, Alessandro, Fiorani, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8306514/
https://ncbi.nlm.nih.gov/pubmed/34299074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147455
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