AUY922 induces retinal toxicity through attenuating TRPM1

BACKGROUND: Ocular adverse events are common dose-limiting toxicities in cancer patients treated with HSP90 inhibitors, such as AUY922; however, the pathology and molecular mechanisms that mediate AUY922-induced retinal toxicity remain undescribed. METHODS: The impact of AUY922 on mouse retinas and...

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Bibliografski detalji
Izdano u:J Biomed Sci
Glavni autori: Shen, Che-Hung, Hsieh, Chi-Che, Jiang, Kuan-Ying, Lin, Chih-Yu, Chiang, Nai-Jung, Li, Ting-Wei, Yen, Chun-Ting, Chen, Wan-Ju, Hwang, Daw-Yang, Chen, Li-Tzong
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8306347/
https://ncbi.nlm.nih.gov/pubmed/34301262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-021-00751-5
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