Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922

Oncogenic mutations of BRAF occur in approximately 10% of colon cancers and are associated with their resistance to clinically available therapeutic drugs and poor prognosis of the patients. Here we report that colon cancer cells with mutant BRAF are also resistant to the heat shock protein 90 (HSP9...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Wang, Chun Yan, Guo, Su Tang, Wang, Jia Yu, Yan, Xu Guang, Farrelly, Margaret, Zhang, Yuan Yuan, Liu, Fen, Yari, Hamed, La, Ting, Lei, Fu Xi, Jin, Lei, Zhang, Xu Dong, Jiang, Chen Chen
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2016
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226532/
https://ncbi.nlm.nih.gov/pubmed/27391062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10414
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