Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922

Oncogenic mutations of BRAF occur in approximately 10% of colon cancers and are associated with their resistance to clinically available therapeutic drugs and poor prognosis of the patients. Here we report that colon cancer cells with mutant BRAF are also resistant to the heat shock protein 90 (HSP9...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Wang, Chun Yan, Guo, Su Tang, Wang, Jia Yu, Yan, Xu Guang, Farrelly, Margaret, Zhang, Yuan Yuan, Liu, Fen, Yari, Hamed, La, Ting, Lei, Fu Xi, Jin, Lei, Zhang, Xu Dong, Jiang, Chen Chen
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226532/
https://ncbi.nlm.nih.gov/pubmed/27391062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10414
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