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AUY922 induces retinal toxicity through attenuating TRPM1
BACKGROUND: Ocular adverse events are common dose-limiting toxicities in cancer patients treated with HSP90 inhibitors, such as AUY922; however, the pathology and molecular mechanisms that mediate AUY922-induced retinal toxicity remain undescribed. METHODS: The impact of AUY922 on mouse retinas and...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Biomed Sci |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BioMed Central
2021
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8306347/ https://ncbi.nlm.nih.gov/pubmed/34301262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-021-00751-5 |
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