Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease

BACKGROUND: Disease-associated microglia (DAMs), that surround beta-amyloid plaques, represent a transcriptionally-distinct microglial profile in Alzheimer’s disease (AD). Activation of DAMs is dependent on triggering receptor expressed on myeloid cells 2 (TREM2) in mouse models and the AD TREM2-R47...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Claes, Christel, Danhash, Emma Pascal, Hasselmann, Jonathan, Chadarevian, Jean Paul, Shabestari, Sepideh Kiani, England, Whitney E., Lim, Tau En, Hidalgo, Jorge Luis Silva, Spitale, Robert C., Davtyan, Hayk, Blurton-Jones, Mathew
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8305935/
https://ncbi.nlm.nih.gov/pubmed/34301296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00473-0
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