Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

The discovery of TREM2 as a myeloid-specific Alzheimer’s disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse models have provided critical insight, the normal and disease-associated functions of TREM2 in human microglia remain unclear. To examine this...

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Publicado en:Nat Commun
Main Authors: McQuade, Amanda, Kang, You Jung, Hasselmann, Jonathan, Jairaman, Amit, Sotelo, Alexandra, Coburn, Morgan, Shabestari, Sepideh Kiani, Chadarevian, Jean Paul, Fote, Gianna, Tu, Christina H., Danhash, Emma, Silva, Jorge, Martinez, Eric, Cotman, Carl, Prieto, G. Aleph, Thompson, Leslie M., Steffan, Joan S., Smith, Ian, Davtyan, Hayk, Cahalan, Michael, Cho, Hansang, Blurton-Jones, Mathew
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584603/
https://ncbi.nlm.nih.gov/pubmed/33097708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19227-5
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