Development of a chimeric model to study and manipulate human microglia in vivo

iPSC-derived microglia offer a powerful tool to study microglial homeostasis and disease-associated inflammatory responses. Yet, microglia are highly sensitive to their environment, exhibiting transcriptomic deficiencies when kept in isolation from the brain. Furthermore, species-specific genetic va...

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Bibliografski detalji
Izdano u:Neuron
Glavni autori: Hasselmann, Jonathan, Coburn, Morgan A., England, Whitney, Velez, Dario X. Figueroa, Shabestari, Sepideh Kiani, Tu, Christina H., McQuade, Amanda, Kolahdouzan, Mahshad, Echeverria, Karla, Claes, Christel, Nakayama, Taylor, Azevedo, Ricardo, Coufal, Nicole G., Han, Claudia Z., Cummings, Brian J., Davtyan, Hayk, Glass, Christopher K., Healy, Luke M., Gandhi, Sunil P., Spitale, Robert C., Blurton-Jones, Mathew
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138101/
https://ncbi.nlm.nih.gov/pubmed/31375314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.07.002
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