Development of a chimeric model to study and manipulate human microglia in vivo

iPSC-derived microglia offer a powerful tool to study microglial homeostasis and disease-associated inflammatory responses. Yet, microglia are highly sensitive to their environment, exhibiting transcriptomic deficiencies when kept in isolation from the brain. Furthermore, species-specific genetic va...

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Vydáno v:Neuron
Hlavní autoři: Hasselmann, Jonathan, Coburn, Morgan A., England, Whitney, Velez, Dario X. Figueroa, Shabestari, Sepideh Kiani, Tu, Christina H., McQuade, Amanda, Kolahdouzan, Mahshad, Echeverria, Karla, Claes, Christel, Nakayama, Taylor, Azevedo, Ricardo, Coufal, Nicole G., Han, Claudia Z., Cummings, Brian J., Davtyan, Hayk, Glass, Christopher K., Healy, Luke M., Gandhi, Sunil P., Spitale, Robert C., Blurton-Jones, Mathew
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138101/
https://ncbi.nlm.nih.gov/pubmed/31375314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.07.002
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