Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria

Heterologous expression of biosynthetic gene clusters (BGCs) avails yield improvements and mining of natural products, but it is limited by lacking of more efficient Gram-negative chassis. The proteobacterium Schlegelella brevitalea DSM 7029 exhibits potential for heterologous BGC expression, but it...

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Udgivet i:Nat Commun
Main Authors: Liu, Jiaqi, Zhou, Haibo, Yang, Zhiyu, Wang, Xue, Chen, Hanna, Zhong, Lin, Zheng, Wentao, Niu, Weijing, Wang, Sen, Ren, Xiangmei, Zhong, Guannan, Wang, Yan, Ding, Xiaoming, Müller, Rolf, Zhang, Youming, Bian, Xiaoying
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302735/
https://ncbi.nlm.nih.gov/pubmed/34301933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24645-0
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