Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species

Bacterial genomes encode numerous cryptic biosynthetic gene clusters (BGCs) that represent a largely untapped source of drugs or pesticides. Mining of the cryptic products is limited by the unavailability of streamlined genetic tools in native producers. Precise genome engineering using bacteriophag...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Xue, Zhou, Haibo, Chen, Hanna, Jing, Xiaoshu, Zheng, Wentao, Li, Ruijuan, Sun, Tao, Liu, Jiaqi, Fu, Jun, Huo, Liujie, Li, Yue-zhong, Shen, Yuemao, Ding, Xiaoming, Müller, Rolf, Bian, Xiaoying, Zhang, Youming
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939090/
https://ncbi.nlm.nih.gov/pubmed/29666226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720941115
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