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Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering
Disorazol, a macrocyclic polykitide produced by the myxobacterium Sorangium cellulosum So ce12 and it is reported to have potential cytotoxic activity towards several cancer cell lines, including multi-drug resistant cells. The disorazol biosynthetic gene cluster (dis) from Sorangium cellulosum (So...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4753468/ https://ncbi.nlm.nih.gov/pubmed/26875499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21066 |
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