Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome

Dravet syndrome (DS) is a rare genetic encephalopathy that is characterized by severe seizures and highly resistant to commonly used antiepileptic drugs (AEDs). In 2020, FDA has approved fenfluramine (FFA) for treatment of seizures associated with DS. However, the clinically used FFA is a racemic mi...

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Detalhes bibliográficos
Publicado no:Neurochem Res
Main Authors: Li, Jing, Nelis, Maxim, Sourbron, Jo, Copmans, Daniëlle, Lagae, Lieven, Cabooter, Deirdre, de Witte, Peter A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2021
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302504/
https://ncbi.nlm.nih.gov/pubmed/34041623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-021-03358-2
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