Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome

Dravet syndrome (DS) is a rare genetic encephalopathy that is characterized by severe seizures and highly resistant to commonly used antiepileptic drugs (AEDs). In 2020, FDA has approved fenfluramine (FFA) for treatment of seizures associated with DS. However, the clinically used FFA is a racemic mi...

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Vydáno v:Neurochem Res
Hlavní autoři: Li, Jing, Nelis, Maxim, Sourbron, Jo, Copmans, Daniëlle, Lagae, Lieven, Cabooter, Deirdre, de Witte, Peter A. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2021
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302504/
https://ncbi.nlm.nih.gov/pubmed/34041623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-021-03358-2
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