Pharmacological Analysis of the Anti-epileptic Mechanisms of Fenfluramine in scn1a Mutant Zebrafish

Dravet syndrome (DS) is a genetic encephalopathy that is characterized by severe seizures and prominent co-morbidities (e.g., physical, intellectual disabilities). More than 85% of the DS patients carry an SCN1A mutation (sodium channel, voltage gated, type I alpha subunit). Although numerous anti-e...

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Publicat a:Front Pharmacol
Autors principals: Sourbron, Jo, Smolders, Ilse, de Witte, Peter, Lagae, Lieven
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382218/
https://ncbi.nlm.nih.gov/pubmed/28428755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00191
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