Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome

Dravet syndrome (DS) is a rare genetic encephalopathy that is characterized by severe seizures and highly resistant to commonly used antiepileptic drugs (AEDs). In 2020, FDA has approved fenfluramine (FFA) for treatment of seizures associated with DS. However, the clinically used FFA is a racemic mi...

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Bibliografiska uppgifter
I publikationen:Neurochem Res
Huvudupphovsmän: Li, Jing, Nelis, Maxim, Sourbron, Jo, Copmans, Daniëlle, Lagae, Lieven, Cabooter, Deirdre, de Witte, Peter A. M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer US 2021
Ämnen:
Original Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302504/
https://ncbi.nlm.nih.gov/pubmed/34041623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-021-03358-2
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