Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome

Dravet syndrome (DS) is a rare genetic encephalopathy that is characterized by severe seizures and highly resistant to commonly used antiepileptic drugs (AEDs). In 2020, FDA has approved fenfluramine (FFA) for treatment of seizures associated with DS. However, the clinically used FFA is a racemic mi...

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Detaylı Bibliyografya
Yayımlandı:Neurochem Res
Asıl Yazarlar: Li, Jing, Nelis, Maxim, Sourbron, Jo, Copmans, Daniëlle, Lagae, Lieven, Cabooter, Deirdre, de Witte, Peter A. M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer US 2021
Konular:
Original Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302504/
https://ncbi.nlm.nih.gov/pubmed/34041623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-021-03358-2
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