Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function

The frequencies of genetic variants in the CYP3A4 and CYP3A5 genes differ greatly across global populations, leading to profound differences in the metabolic activity of these enzymes and resulting drug metabolism rates, with important consequences for therapeutic safety and efficacy. Yet, the impac...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Fohner, Alison E., Dalton, Rachel, Skagen, Kasse, Jackson, Konner, Claw, Katrina G., Hopkins, Scarlett E., Robinson, Renee, Khan, Burhan A., Prasad, Bhagwat, Schuetz, Erin G., Nickerson, Deborah A., Thornton, Timothy A., Dillard, Denise A., Boyer, Bert B., Thummel, Kenneth E., Woodahl, Erica L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301563/
https://ncbi.nlm.nih.gov/pubmed/33503331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12970
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