Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function

The frequencies of genetic variants in the CYP3A4 and CYP3A5 genes differ greatly across global populations, leading to profound differences in the metabolic activity of these enzymes and resulting drug metabolism rates, with important consequences for therapeutic safety and efficacy. Yet, the impac...

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Библиографические подробности
Опубликовано в: :Clin Transl Sci
Главные авторы: Fohner, Alison E., Dalton, Rachel, Skagen, Kasse, Jackson, Konner, Claw, Katrina G., Hopkins, Scarlett E., Robinson, Renee, Khan, Burhan A., Prasad, Bhagwat, Schuetz, Erin G., Nickerson, Deborah A., Thornton, Timothy A., Dillard, Denise A., Boyer, Bert B., Thummel, Kenneth E., Woodahl, Erica L.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2021
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301563/
https://ncbi.nlm.nih.gov/pubmed/33503331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12970
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