Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function

The frequencies of genetic variants in the CYP3A4 and CYP3A5 genes differ greatly across global populations, leading to profound differences in the metabolic activity of these enzymes and resulting drug metabolism rates, with important consequences for therapeutic safety and efficacy. Yet, the impac...

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Detalles Bibliográficos
Publicado en:Clin Transl Sci
Main Authors: Fohner, Alison E., Dalton, Rachel, Skagen, Kasse, Jackson, Konner, Claw, Katrina G., Hopkins, Scarlett E., Robinson, Renee, Khan, Burhan A., Prasad, Bhagwat, Schuetz, Erin G., Nickerson, Deborah A., Thornton, Timothy A., Dillard, Denise A., Boyer, Bert B., Thummel, Kenneth E., Woodahl, Erica L.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2021
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301563/
https://ncbi.nlm.nih.gov/pubmed/33503331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12970
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