Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL-Rearranged Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) in infants (<1 year of age) remains one of the most aggressive types of childhood hematologic malignancy. The majority (~80%) of infant ALL cases are characterized by chromosomal translocations involving the MLL (or KMT2A) gene, which confer highly dismal progno...

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Publicado en:Biomedicines
Main Authors: Kerstjens, Mark, Garrido Castro, Patricia, Pinhanços, Sandra S., Schneider, Pauline, Wander, Priscilla, Pieters, Rob, Stam, Ronald W.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301450/
https://ncbi.nlm.nih.gov/pubmed/34201500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9070711
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