Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants

Acute lymphoblastic leukemia in infants represents an aggressive malignancy associated with a high incidence (approx. 80%) of translocations involving the Mixed Lineage Leukemia (MLL) gene. Attempts to mimic Mixed Lineage Leukemia fusion driven leukemogenesis in mice raised the question whether thes...

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Hauptverfasser: Driessen, Emma M.C., van Roon, Eddy H.J., Spijkers-Hagelstein, Jill A.P., Schneider, Pauline, de Lorenzo, Paola, Valsecchi, Maria Grazia, Pieters, Rob, Stam, Ronald W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2013
Schlagworte:
Original Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669451/
https://ncbi.nlm.nih.gov/pubmed/23403319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.067983
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