Physiologically based modelling of tranexamic acid pharmacokinetics following intravenous, intramuscular, sub-cutaneous and oral administration in healthy volunteers

BACKGROUND: : Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood loss and death due to bleeding after trauma and post-partum haemorrhage. Treatment success is dependant on early intervention and rapid systemic exposure to TXA. The requirement for intravenous (IV) administr...

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Detalhes bibliográficos
Publicado no:Eur J Pharm Sci
Main Authors: Kane, Zoe, Picetti, Roberto, Wilby, Alison, Standing, Joseph F., Grassin-Delyle, Stanislas, Roberts, Ian, Shakur-Still, Haleema
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science B.V 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8299544/
https://ncbi.nlm.nih.gov/pubmed/34087356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2021.105893
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