Physiologically based modelling of tranexamic acid pharmacokinetics following intravenous, intramuscular, sub-cutaneous and oral administration in healthy volunteers

BACKGROUND: : Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood loss and death due to bleeding after trauma and post-partum haemorrhage. Treatment success is dependant on early intervention and rapid systemic exposure to TXA. The requirement for intravenous (IV) administr...

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Pubblicato in:Eur J Pharm Sci
Autori principali: Kane, Zoe, Picetti, Roberto, Wilby, Alison, Standing, Joseph F., Grassin-Delyle, Stanislas, Roberts, Ian, Shakur-Still, Haleema
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Science B.V 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8299544/
https://ncbi.nlm.nih.gov/pubmed/34087356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2021.105893
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