The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma

Ewing sarcoma is an aggressive bone cancer of children and young adults defined by the presence of a chromosomal translocation: t(11;22)(q24;q12). The encoded protein, EWS/FLI, fuses the amino-terminal domain of EWS to the carboxyl-terminus of FLI. The EWS portion is an intrinsically disordered tran...

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Udgivet i:Oncogene
Main Authors: Boone, Megann A., Taslim, Cenny, Crow, Jesse C., Selich-Anderson, Julia, Byrum, Andrea K., Showpnil, Iftekhar A., Sunkel, Benjamin D., Wang, Meng, Stanton, Benjamin Z., Theisen, Emily R., Lessnick, Stephen L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8298202/
https://ncbi.nlm.nih.gov/pubmed/34145397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01876-5
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